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O.T. -- LeSean McCoy injured in practice today....

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PITTSFORD, N.Y. (AP) — Buffalo Bills running back LeSean McCoy hurt his left hamstring during a joint practice with Cleveland and is having tests to determine the extent of the injury.

Coach Rex Ryan said Tuesday night that trainers informed him the hamstring is intact and has not been pulled off the bone, which he described as "a real positive."

McCoy pulled up short and started limping during 7-on-7 drills about an hour into practice. He walked to the sideline holding the back of his left leg, and then sat on the turf, where he was attended to by numerous trainers. He required help getting up, and then slowly made his way to the locker room.

McCoy led the NFL with 1,607 yards rushing in 2013 while with Philadelphia. He was acquired by the Bills in a trade for linebacker Kiko Alonso this offseason.

Ryan didn't want to be pinned down on a timetable as to how much time McCoy could miss.

"I really don't want to go there yet, because let's get the prelim reports," he said. "Hopefully, this will be something that doesn't set him back too far."

The injury is the latest in a long string of ailments for Buffalo's depleted group of running backs.

It likely leaves the Bills with just two healthy backs — undrafted rookies Bronson Hill and Ricky Seale — for their game at Cleveland on Thursday night. Seale had just signed with Buffalo earlier in the day after Karlos Williams was taken to a hospital and had an undisclosed medical procedure on Monday.

Without discussing the nature of the procedure, Ryan said Williams will miss about two weeks.

Veteran Fred Jackson has missed two weeks after hurting his hamstring. He is expected to resume practicing next week.

Boobie Dixon, another veteran backup, is expected to miss another two weeks after pulling a calf muscle. And Bryce Brown is out with an undisclosed injury.

The Bills also are down their top three receivers.

Sammy Watkins missed practice after experiencing tightness in his hamstring and pain in a gluteal muscle. Ryan said Robert Woods missed practice on Tuesday after experiencing tightness, without specifying. Percy Harvin is expected to miss at least a week with an undisclosed injury.

That left Ryan wondering what the makeup of his patchwork offense will resemble on Thursday.

"Probably as not good as we anticipate going into the season with," Ryan said. "I don't know fellas.
 
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