Pitt will move the ball between the 25 yard lines but will have trouble converting drives into points due to defensive pressure, noise affecting audibles and counts particularly when they are driving toward the south end zone into the teeth of 25k hollering students, and questions with the kicking game. With the linebackers healthy the expectation will be to keep Pitt's run reasonably in check in base defense. Pitt's offense will be moving around a lot prior to the snap, but expect PSU's D to stay at home and not get pulled out of position as much as they did last year. They'll be keying on Henderson early because he is such a threat. If PSU can get pressure on a 4-man rush it's going to be tough for Browne to get much going with the pass.
On offense PSU will rack up yards with Narduzzi selling out against the run and leaving the secondary in space defending big receiving targets one on one. In particular, Johnson and Gesicki will have advantages of 6"-8" in height and 50-60 lbs in weight on the CB or S covering them in man. They'll be tough assignments and will be expecting passes to the back shoulder where their length and vertical jump give them the only chance at the ball.
Look for some read option early in the game, with McSorley keeping when the DE, MLB, and OLB key on the RB, or flipping the ball over the DL to the slot receiver on the RPO. The defense will have to pick its poison - giving up the intermediate pass or settling back into coverage at risk of getting gashed on the run. Comes down to PSU's ability to execute.
At some point you'll probably see #9 under center and #2 on the flank, maybe with #26 on the LOS which could open up some very interesting plays. PSU feels very good about its offensive weapons and probably can consistently put one more threat on the field than Pitt can defend.
I won't put a score here on your board, but will predict that PSU gets over 500 yards in offense and covers the spread.