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OT: article on Pitt prof Sahel's plans to make Pitt a leader in vision restoration

CrazyPaco

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Jul 5, 2001
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I thought this was a good article that describes what Pitt and UPMC are trying to accomplish in vision research since recruiting José-Alain Sahel to Pitt in 2016. The article is behind a pay wall at the Pittsburgh Business Times, but is an important undertaking for Pitt, so here it is in two parts.

Creating a new vision: Dr. Jose-Alain Sahel aims to make Pittsburgh a leading center for sight restoration

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Dr. Jose-Alain Sahel is the Chairman, Department of Opthamalogy at the University of Pittsburgh’s Eye & Ear Institute.
Joe Wojcik

By Paul J. Gough – Reporter, Pittsburgh Business Times
Nov 29, 2018, 7:42am EST Updated Nov 29, 2018, 8:51am EST


For Dr. José-Alain Sahel, one of the leading global experts in ophthalmology, time is of the essence when it comes to getting the UPMC Vision and Rehabilitation Hospital up and running.

Sahel moved to Pittsburgh two years ago to take over the UPMC Eye Center and the University of Pittsburgh School of Medicine’s Department of Ophthalmology. Since then, he’s been working tirelessly to make Pittsburgh a groundbreaking center of vision and rehabilitation that will work with the Vision Institute in Paris, which he founded and still directs.

“I don’t see we should wait any day,” Sahel said. “People suffering from vision loss don’t want to wait, and we should never accept any delay when people are waiting for therapy.”

There has already been some delay on the $200 million-plus, 410,000-square-foot facility that will be built on the grounds of UPMC Mercy. It’s the first of three specialty hospitals costing a total of $2 billion that will be built by UPMC over the next five years. And it will not only focus on vision, but also be the center of UPMC’s physical rehabilitation services.

Because it is the first of the three hospitals being built, the UPMC Vision and Rehabilitation Hospital was a lightning rod before the Pittsburgh Planning Commission and City Council. UPMC’s plans to change Mercy’s master plan to accommodate the hospital drew overflow crowds and hours of opposing testimony, as well as a protest march from UPMC’s headquarters to City Council. A public hearing that lasted more than four hours drew more than 100 speakers, most opposed to the plan.

But Sahel and others involved in the project say the benefits of the hospital — including to the region surrounding where it will be located — has gotten lost in the controversy. The center and Sahel’s body of work comes at a confluence of breakthroughs into how vision and the brain work that has the potential to restore sight, something that was once thought to be the realm of science fiction.

‘We are in your backyard’

Sahel sees the UPMC Vision and Rehabilitation Hospital as a logical extension and expansion of what he has done in Paris with the Vision Institute, which has grown in 10 years to become a global hub for treatment and research. It’s a convergence of clinical practices, biotherapies, technology, artificial intelligence, all with a humanistic approach that never forgets the patient is at the center of it all.

Sahel has reached out to foundations, investment funds and the corporate sector for one part of the hospital’s strategy, which is building a vibrant ecosystem of vision and rehabilitation companies that grow up in the neighborhood. That’s what happened in Paris, where the institute and Sahel spawned more than 10 companies and 1,000 jobs.

“Our goal here is to duplicate that, to do maybe better, to create new companies, to create jobs,” Sahel said.

The Paris neighborhood around the Vision Institute had been losing population and industry for years. But now the biotech sector has reinvigorated it, said Lawton Snyder, CEO of the Eye & Ear Foundation of Pittsburgh.

“That’s what we see for Pittsburgh,” Snyder said.

Uptown Partners of Pittsburgh, a neighborhood development group, expects a big boost in investment and vibrancy in the neighborhoods around UPMC Mercy once the new hospital opens.

“The development represents an exciting catalytic economic development opportunity and a new benchmark for health and wellness in the region,” said Jeanne McNutt, executive director of Uptown Partners. McNutt and Uptown Partners were one of the handful of groups to show support for the project in August’s City Council public hearing.

McNutt said the hospital is just a start. With it she said will come more development, including retail and green space, along with the promise of even more reinvestment, thanks to the community benefits agreement UPMC brokered with City Council member Daniel LaVelle.

One organization focused on helping those whose eyesight is impaired, the Blind & Vision Rehabilitation Services of Pittsburgh, is already in Uptown. When the nonprofit moved there in 2016, it had no clue how important its location would be in just a few years. President Erika Petach can see where the hospital will be located from the boardroom windows, less than two blocks away.

Sahel visited the nonprofit immediately after arriving in Pittsburgh. He immediately saw the potential for collaboration.

“He was excited,” Petach recalled. “He said, ‘We are in your backyard!’”

Sahel joined the nonprofit’s board and believes the two organizations, along with Duquesne University and the City of Pittsburgh, could do groundbreaking things in the years ahead. Sahel has talked to Pittsburgh Mayor Bill Peduto and others about making Uptown Pittsburgh a friendlier neighborhood for the visually impaired. There are existing technologies as well as other types of innovation in sidewalks and other infrastructure that could be employed, Sahel and Petach said.

“They are things that would make it easy for people to get back and forth between the two organizations,” Petach said.
 
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‘We should not accept any limit’

Yet, building the hospital and these programs are expensive. While UPMC is committed to funding the hospital and the equipment, assembling the money to recruit the world-class cutting edge researchers and their startup costs is the goal of the Eye & Ear Foundation. The fundraising campaign, “A New Vision for Pittsburgh,” will be the largest in the nonprofit’s history, although the amount hasn’t been disclosed.

About 18 scientists have already signed on, and more will be on the way. The Eye & Ear Foundation, which is a part of Pitt, is recruiting not just on a national basis, but a global one, too.

The Vision Institute in Paris is already a big partner in these efforts. Several researchers, along with Sahel, are sharing time between Pittsburgh and Paris. That will only increase when the UPMC Vision and Rehabilitation Hospital is up and running, said George Fechter, chairman of the board of the Eye & Ear Foundation.

“Together they represent the largest academic study of ophthalmology anywhere in the world,” Fechter said.

Dr. Donald J. Zack, a professor of ophthalmology at Johns Hopkins University and the Wilmer Eye Institute and co-director of the Johns Hopkins Center for Stem Cells and Ocular Regenerative Medicine, believes Sahel will do in Pittsburgh what he did in Paris: Create another world-class center for eye research and eye care.

“He will integrate great basic science, translational science and modeling and great clinical care to translate this technology that is going to help patients,” Zack said. “That’s really what this hospital has the potential to do.”

Zack, who was a resident when Sahel was a fellow, said Sahel has a talent for bringing academics and industry together to solve problems.

“He has a unique ability to extract the best from people and synergize,” Zack said.

Vascular eye disease, age-related macular degeneration and retinitis pigmentosa were all thought to be irreversible. But Sahel said innovations by these researchers, along with others, show promise.

These innovations will be at the heart of the new UPMC Vision and Rehabilitation Hospital, where novel therapies that will help blind and low-vision people will be developed.

Gene therapy, for one. Not only is UPMC trying to get access to a gene therapy that was recently approved for use in the U.S., but it’s also developing five new gene therapies. Sahel is working with researchers in California and Paris on an artificial retina, a small chip in the retina that would stimulate neurons and go to the brain. Trials have shown letter recognition for people who have had the technology implanted.

“Pittsburgh will be the first city in America to benefit from this technology,” Sahel said.

Furthermore, work being done across the hall from Sahel’s office by Ethan Rossi, assistant professor of ophthalmology who was Sahel’s first recruit to Pittsburgh, has led to a new, noninvasive way to image the retina, which is allowing for better views of the layers of cells behind the eyes.


“We will be able to follow the progression of disease on almost a weekly basis vs. monthly or yearly,” Sahel said. “This will be very important to assess for disease in patients’ lives and also to assess the efficiency of therapies.”

And work by James and Martha Funderburgh at Pitt using stem cells to treat blindness is already restoring eye sight in India, and Sahel wants to see this done in Pittsburgh.

“We should not accept any limit in what we want to do, except for technological limits, and we have to break those limits,” Sahel said.

Changes already underway

Yet, breaking these limits comes with challenges. Immediately upon arriving in Pittsburgh, Sahel also identified gaps in UPMC’s offerings and set about filling them. He’s constantly talking to people about the opportunities around the UPMC Vision and Rehabilitation Hospital. He’s addressing the existing flow of patients and the patient experience, assessing efficiency and technology, and making things better in the existing building at UPMC Presbyterian.

“The plan is to be, when the (new) building is open, to be already up and running,” Sahel said.

The project, while advancing behind the scenes, faced delays during 2018 while a plan to change UPMC Mercy’s master plan ran into opposition from some community groups, first at the Planning Commission and then at City Council. Sahel acknowledges feeling frustrated about the opposition to the plan for the hospital, because for him the project has always been about helping people.

“I was very sad, actually. I thought nobody wanted to understand what we wanted to bring. I thought it was unfair, not just to me, but it was unfair for what is being done,” Sahel said. “We are working for the past two years on really bringing something new to the city, and bringing jobs, bringing new care. So I don’t see losing anything from that. I see ... losing from all this chaos and the time we wasted on that.”

Sahel, who testified in the early stages of the City Council’s public hearing, said there was a lot of misunderstanding. Chief among that is the concern that the UPMC Vision & Rehabilitation Hospital wasn’t being built for Pittsburgh.

“I had decided I would stay for four hours, but when I heard someone say that we are going to create a hospital for the rich that don’t live in Pennsylvania, for foreigners, that nothing would be benefiting the people here, I decided to quit (the hearing). It’s so exactly the opposite of what we are trying to do, it’s exactly the opposite,” he said.

For Sahel, Pittsburgh is at the nexus of technology, research and clinical skills that can help people who have vision impairment or blindness. The time is now.

“Talking about restoring vision was something you wouldn’t dare to do 10 years ago,” Sahel said. “Now it’s time to talk about it. Not for everyone, unfortunately, but for several types of patients.”


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The Eye & Ear Foundation— supporting the Departments of Ophthalmology and Otolaryngology at the University of Pittsburgh School of Medicine: http://eyeandear.org/
 
Oh yeah? Well, the PS creamery plans something equally revolutionary ... a ribbon of raspberry jam through the peachy paterno. "Success With Melba" is the working name. There is significant debate raging whether the raspberry will be with or without seeds. Franco is said to be apoplectic over the blaspheme of the idea. Scott Paterno has demanded several gallons of the prototype and the original for evaluation and comparison. News vans are being given extra protective cladding as a contingency over possible local outrage. The Post Gazette has dispatched a(nother) full time reporter up there to cover it for the next eight months.
 
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And isn't it interesting that Pittsburgh and PA were ready to give away over $7,000,000,000 to Amazon so they could come in and ruin the city. Meanwhile we can build this city the way know how; from the inside out. So why the opposition?
 
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