I guess my question would be, how are you going to do that. Can you put a cloud over Washington, or even bracket him? Yes. Will that leave you even more vulnerable to the deep ball? Yes.
Here's part of your problem. The table below includes updated statistics on everyone on both rosters that are either a WR or a TE, and their career yardage:
PITT...................Catches........Yards.........TDs
Weah ...................43.............. 948 ..........11
Henderson ..........31 ..............299 ............1
Flanagan ............23 ..............199 .............3
Tipton .................12 ..............142............. 1
Araujo-Lopes .......8 ................83............. 0
Matthews .............8................ 69 ..............0
Sear .....................1................ 10............ 0
Gragg ...................1 ...............10 .............0
Total .................127............ 1760 ...........16
Oklahoma St .....Catches....... Yards .......TDs
Washington .........160 ...........3166 .........29
Ateman .................96 ............1436 ...........7
McClesky ...........107 ............1082 ..........10
Lacy ....................48 ...............723 ............5
T Johnson ..........14 ...............237 .............3
Stoner ................11 .................69 .............0
Wallace ...............1 ..................7 ..............0
Total .................437 ...........6720 .............54
Bleacher Report ranked OSU's WR corps the deepest and best in the nation for 2017.
So, you violate your Cover 4 concept and commit a safety to spy on Washington. You're now leaving two of the others listed above in man-to-man coverage, with one of your quarters coverage zones left empty or keeping too much of an eye on Washington. Rudolph pump fakes to Washington, the safety bites and he drops a bomb on Lacy or Ateman.
If you're successful in covering everyone, Rudolph checks down to McClesky in the slot, or 2016 Freshman All American RB, Justice Hill, who only saw limited action against you guys last season, because we didn't yet know what we had.
Finally, to add insult to injury, OSU runs two plays with the starters (Lacy, Washington and McClesky), then subs them out like a hockey line for Ateman, Johnson and Stoner. Maddox is now gassed from covering Washington on two deep routes.
Question: Do you leave winded Maddox in to cover five-star LSU Transfer Johnson, or do you sub him out for your second team CB?
That is your DC's dilemma.
BTW...if you don't recognize Ateman or Johnson's names, it's because they didn't play in last year's game in Stillwater. Ateman was injured and Johnson was fulfilling his year sitting out due to his transfer.
Here's a link to his high school recruiting page.